A regimen is a set of rules about food and exercise that some people follow in order to stay healthy . Steps Involved in Individualization of Dosage Regimen. When you have addiction to something it is called being addicted or being an addict.People can be addicted to drugs, cigarettes, alcohol, caffeine, and many other things.. regimen. During 386 tests there were four episodes of ventricular dysrhythmias (two complex ventricular extra beats, one non-sustained ventricular tachycardia, and one ventricular fibrillation). A dosage guides a drug regimen. When the interval of drug dosing is shorter than that required for the drug to be completely eliminated by the body between doses, the plasma drug levels accumulate. This integration of MIC values and drug concentration measurements in Bayesian individualization of dosage regimens of anti-TB drugs has been recently advocated by the group led by Gumbo [58]. Dosing of Drugs in Neonates, Infants and Children. Because of this, it is important that we should optimize the use of each agent. Not every antihistamine will be effective in any one patient, so several agents and dosage regimens may need to be tested in order to achieve control of pruritus. This could mean starting with 20 to 40 mg a day. 2 the optimum therapeutic dose and optimum interval between doses. There was no significant difference in serum creatinine concentration between the groups during the study, a dosage of amikacin 15 mg/kg/day achieved higher peak and lower trough concentrations in all infants. As pointed out above, available data on anti-TB drug toxicity are not sufficient to derive quantitative relationships between drug PK and adverse drug reactions and define the upper limits for safe exposure. This very well-used approach is discussed in the chapter on transplantation. The public health, fixed-dose approach ignores important determinants of the response to treatment, including the large PK variability in the PK of anti-TB drugs, variability in M. tuberculosis susceptibility to drugs (MIC), and the existence of quantitative exposure–effect relationships. … McGraw-Hill Concise Dictionary of Modern Medicine. Learn more. dosage regimen The schedule of doses of a therapeutic agent per unit of time, including: the time between doses (e.g., every 6 hours) or the time when the dose(s) are to be given (e.g., at 8 a.m. and 4 p.m. daily), and the amount of a medicine (e.g., number of capsules) to be given at each specific time. Dose adjustment in Renal and hepatic impairment. From: Reproductive and Developmental Toxicology (Second Edition), 2017, S. Goutelle, P. Maire, in Individualized Drug Therapy for Patients, 2017. Very importantly, PK variability of single anti-TB drugs has been shown to influence the clinical outcome of combination therapy [21,26,45]. n. 1 the administration of a drug or agent in prescribed amounts. In contrast to continuous infusions, with intermittent drug dosing, levels rise and fall between drug doses. The 10-day melarsoprol regimen is effective and easier to administer than longer regimens. They may prescribe a combination of drugs. See also: dosage, dose, doge, dotage. The dosage regimen is the frequency at which the drug doses are given. in order to improve your health: His doctor put him on a strict regimen of exercise and low-fat food. mən / (also regime, us / reɪˈʒim, rə- /) a set of rules about food, exercise, or behavior that you follow, esp. However, TB treatment has been rigidly standardized and coordinated at the international level by the WHO, in spite of the increasing scientific evidence supporting individualization of anti-TB dosage drug regimens. Complexity and sophisticated mathematics are not the real issue. The Latin regimen derives from another Latin word, the verb "regere," which means "to lead straight" or "to rule." In addition, technical progress, such as dried blood spots for measurement of drug concentrations [60] may help. Rommel G. Tirona, Richard B. Kim, in Clinical and Translational Science (Second Edition), 2017. As pointed out by Srivastava and Gumbo [58], the main barriers to the development of individual dosing approaches of TB drugs are apparent complexity and cost. 3 another name for → dose → 3, 4. Copyright © 2021 Elsevier B.V. or its licensors or contributors. There is no clinical benefit to be derived from using H2-blockers in the therapy of canine atopic dermatitis, and there is no additive effect to be gained from administration of combined H1- and H2-blockers to such patients. Michael J Day, in Small Animal Clinical Pharmacology (Second Edition), 2008. Patients Weighing 40 kg or More: Pediatric patients weighing 40 kg or more should be dosed according to adult recommendations.. This brochure was developed for clinicians to use with patients while discussing the 12-dose regimen for the treatment of latent TB infection. In the management of pruritus, antihistamines are generally given in conjunction with glucocorticoid, and when pruritus is controlled (generally within 5 days) the glucocorticoid is withdrawn and antihistamine therapy maintained to prevent recurrence of pruritus. The 250-mg tablet of AUGMENTIN should not be used until the child weighs … Modern medicine synonyms, Modern medicine pronunciation, Modern medicine translation, English dictionary definition of Modern medicine. The difference between such regimens is the degree of difference in the peak and trough plasma concentrations with each successive dose. We use cookies to help provide and enhance our service and tailor content and ads. However, 935 patients were lost to follow-up. © 2002 by The McGraw-Hill Companies, Inc. Dosage definition is - the addition of an ingredient or the application of an agent in a measured dose. Aljoša Bavec, in Side Effects of Drugs Annual, 2014, Drug dosage regimens This was a prospective, 52-week, single centre, single arm, intervention study to evaluate the efficacy and safety of sitagliptin on glycaemic control in type 2 diabetes inadequately controlled with gliclazide. The authors recommended the use of a slow rate of infusion. In many respects, the accumulation of drugs administered in multiple doses is the same as that observed following a constant-rate intravenous infusion. Sixteen paediatric patients receiving carboplatin-based chemotherapy, with a median age of 8.7 years, were assessed. 12-Dose Regimen for Latent TB Infection-Patient Education Brochure – Materials available in English, Chinese, Haitian Creole, Marshallese, Spanish, Tagalog, and Vietnamese Languages. Corrado Blandizzi, Carmelo Scarpignato, in Side Effects of Drugs Annual, 2014. Medtalk A treatment plan that specifies dosage, schedule, duration of treatment. Because the world TB burden is mostly born by low-income countries with limited health care systems, our suggestions may sound unrealistic. There is some evidence that the effect of antihistamines may be enhanced by concurrent supplementation with essential fatty acids. Your doctor will decide the best drug forms and treatment regimen for you. There were no differences between the rapid and slow infusion rates. Drug dosage regimens: A prospective, crossover, randomized study assessed the occurrence of cardiac adverse effects associated with different dose regimens of intravenous granisetron. However major progress has been made in the knowledge of those determinants in the last 15 years. | Meaning, pronunciation, translations and examples [54c], Taylor A. Choi, in Side Effects of Drugs Annual, 2014. Of the treated patients 8.7% had an encephalopathy that was fatal 46% of the time. This “one-size-fits-all” dosing approach has had the major advantage of being simple and thus easily applicable worldwide. It would be a great thing for the world when we can change from the fixed-dose approach, where the individual is nothing, to an individualized approach where the individual is everything, as he or she truly should be. Based on the available scientific evidence and current clinical experience, the SPR Collaboration recommends that physicians and authorities consider the following covid-19 treatment protocol for the prophylactic and early treatment of people at high risk or high … (20.3)). Maintenance dose regimens are commonly taken as continuous intermittent doses separated by hours to days. o Within a continuum of care, people with drug dependence should have access to treatment services through multiple entry points. Define dose. Finally, one has to calculate the optimal dosage of drugs to reach predefined targets (AUC24/MIC, Cmax/MIC, or anything else). In adjunct therapy for systemic anaphylaxis, administration of diphenhydramine (0.5–1.0 mg/kg IV to a total dose of 50 mg) has been reported following appropriate management of circulatory collapse. However the individual patient becomes lost in the masses that are treated this way. Today, toxicity of anti-TB drugs remains poorly predictable from drug exposure, and clinical monitoring is always the best way to deal with this issue in individual patients. What is needed to develop this dosing approach is support to develop TDM laboratories, similar to what has been done for microbiology laboratories within the WHO Stop TB program. In addition, creatine phosphokinase (CPK), creatine kinase–myocardial band (CK-MB) and troponin-T values were found to be normal before, as well as 24 h after the granisetron infusion [22C]. See CHAP, CHOP, CMF regimen, Daily regimen, Intermittent regimen, MAC regimen, Ornish regimen, STAMP I regimen, Treatment plan. We totally agree with their views. See more. Scott & Miller (1999) have recommended an initial 14-day trial of antihistamine, followed by withdrawal of the drug to allow clinical relapse. It can prevent unnecessary high drug exposure in patients who only need small doses to get the desired response. If your doctor doesn’t provide a recommendation, it’s best to start with a smaller dosage and gradually increase it. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128033487000150, URL: https://www.sciencedirect.com/science/article/pii/B9780444634078000368, URL: https://www.sciencedirect.com/science/article/pii/B9780444634078000423, URL: https://www.sciencedirect.com/science/article/pii/B9780444626356000267, URL: https://www.sciencedirect.com/science/article/pii/B9780444594990000179, URL: https://www.sciencedirect.com/science/article/pii/B9780444537171010313, URL: https://www.sciencedirect.com/science/article/pii/B9780702028588500130, URL: https://www.sciencedirect.com/science/article/pii/B978012802101900020X, Reproductive and Developmental Toxicology (Second Edition), 2017, A worldwide yearly survey of new data in adverse drug reactions, Corrado Blandizzi, Carmelo Scarpignato, in, A worldwide yearly survey of new data in adverse drug reactions and interactions, Meyler's Side Effects of Drugs (Sixteenth Edition), Small Animal Clinical Pharmacology (Second Edition), Clinical and Translational Science (Second Edition), Journal of Allergy and Clinical Immunology. ‘It can arise due to poor adherence to treatment, inappropriate prescription, irregular drug supply, or poor drug quality.’ ‘The general practitioners recorded days of illness, physical signs, and antibiotic prescription.’ ‘Inappropriate use of the available data could result in prescription of incorrect dosages.’ It may also be most useful to monitor both the disease response and concentration-dependent toxicities when high doses appear necessary in other individuals, by controlling the drug exposure most precisely [59], in combination with careful clinical monitoring. treatment permits an adequate response in each community. Dosing in Geriatrics. first-line drug in English translation and definition "first-line drug", Dictionary English-English online. This may involve the testing of a number of different antihistamine drugs in sequence, with each agent being evaluated for clinical effect over a 7–14 day period. drug regimen definition in the English Cobuild dictionary for learners, drug regimen meaning explained, see also 'drug addict',gateway drug',recreational drug',smart drug', English vocabulary By continuing you agree to the use of cookies. COBUILD Advanced English Dictionary. Drug dosage regimens Neonates (n = 30) with suspected or proven sepsis were randomized to amikacin 15 mg/kg/day or 7.5 mg/kg/bd [6c]. The translation of PK/PD concepts into clinical practice requires methods to monitor and control the PK/PD response to anti-TB drugs not just for populations of patients, but especially for each individual patient. Then, one should monitor the patient’s therapy using TDM, collect individual PK data, model the drug behavior, and derive the quantities (AUC24, Cmax) linked to the response. Antipsychotic drug treatment is a key component of schizophrenia treatment recommendations by the National Institute of Health and Care Excellence (NICE), the American Psychiatric Association, and the British Society for Psychopharmacology. a Each strength of suspension of AUGMENTIN is available as a chewable tablet for use by older children.. b Duration of therapy studied and recommended for acute otitis media is 10 days.. Whatever regimen has been prescribed should be rigorously followed. The antihistamines that appear most efficacious in the dog include oxatomide, clemastine, cyproheptadine and amitriptyline (achieving control of pruritus in 16–33% of cases) and in the cat chlorphenamine (chlorpheniramine), oxatomide, clemastine and cyproheptadine are reported to be clinically effective in 40–73% of published cases. While individualized therapy may not yet be economically feasible in such low-income countries, it is entirely realistic and certainly can begin in the more developed areas. In particular, quantitative relationships between anti-TB drug exposure (eg, AUC24 or Cmax) and antimicrobial effect, emergence of resistance, and clinical outcome itself have been determined and now can provide rational target values to be selected and achieved for patients. Schizophrenia is a serious mental disorder in which people interpret reality abnormally. Fair treatment definition: Your treatment of someone is the way you behave towards them or deal with them. In patients receiving 40 mcg/kg granisetron, bradycardia was observed. Effective antihistamine therapy is problematic in the dog and cat, and the owner and veterinary surgeon must be prepared to invest some time in optimizing a regimen for any individual patient. English Collins Dictionary - English Definition & Thesaurus. n. 1. a. Suggested dosage regimens for the use of H1-blockers in the management of pruritus have been reviewed in an excellent paper by Scott & Miller (1999), and these data are reproduced here (Tables 11.2 and 11.3). The initial dosage of gliclazide (30.0 ± 12.0 mg/day) was significantly decreased from the original dosage of gliclazide (36.7 ± 18.4 mg/day). A shortening of the PR interval was also recorded in those treated with 10 mcg/kg granisetron. Dosage regimens recommended by the WHO and public health agencies for treating both drug-usceptible and drug-resistant TB consist of fixed doses or doses adjusted to body weight. ... Those with a history of previous treatment who had pan-susceptible disease would receive HREZ (first-line drugs). This is the job of microbiology laboratories that are already aided by the WHO within its Stop TB strategy [5]. Whereas, the dosage is the dose, or amount of drug, attached to a time-frequency. The case fatality rate was 5.9%. As the world develops, in future years, it may well be possible for this approach to spread further into these presently underserved areas. This activity can be centralized, with reference centers performing it for a defined geographical area, just as transplant therapy is now individualized by a central reference service over the web for many areas of France. The use of PK/PD concepts and easy-to-use Bayesian PK software currently available on laptop computers in clinical practice simply requires proper training of users, like any other technique in medicine. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Copyright © HarperCollins Publishers. If the MIC is not available yet (eg, at the start of therapy) or cannot be determined, one should use the most probable value, based on the local microbial epidemiology (MIC distribution). Hydroxychloroquine or chloroquine, a treatment for malaria, lupus erythematosus, and rheumatoid arthritis, has been under study as a possible treatment for COVID-19. The dose interval may then be increased to # hours for another # weeks of treatment. A. Finzi, in Side Effects of Drugs Annual, 2012. We are concerned that the fixed-dose paradigm in TB treatment is unlikely to change unless major clinical evidence shows the superiority of another dosing approach. Thus, one should not think that combination therapy can necessarily compensate for poor dosing of individual drugs. Dosage regimens recommended by the WHO and public health agencies for treating both drug-usceptible and drug-resistant TB consist of fixed doses or doses adjusted to body weight. Drug dosage regimens The prodysrhythmic risk of the use of rapid and slow infusion rates of ajmaline (1 mg/kg at a rate of 1 mg/second or over 10 minutes) in the diagnosis of Brugada syndrome has been studied in 32 patients (mean age 41 years) [26c]. Current data shows that this drug does not reduce deaths among hospitalised COVID-19 patients, nor help people with moderate disease. Factors such as cost and frequency of dosing should be considered in selection of an appropriate antihistamine for any individual case. There is an urgent need for clinical trials comparing individualized, goal-oriented, model-based dosages versus fixed-dose regimens of anti-TB drugs. Melarsoprol dosage regimens vary; usually three or four series of three or four injections of increasing doses are given, with rest periods of 7–10 days. The total daily dose is calculated from the dose and the number of times per day the dose is taken. These results show that when combined with sitagliptin (final dosage 64.6 ± 23.2 mg/day), low dosages of gliclazide is sufficient for glycaemic control in type 2 diabetes. https://medical-dictionary.thefreedictionary.com/dosage+regimen, With the exception of the number of prior lines of treatment, the eligibility criteria were similar to and the, The present study aimed to investigate the interspecies variations in relation to pharmacokinetic profile and optimal, The model might be used in initiating a vancomycin, In comparison with FIGO 2017 misoprostol recommendations, we found that a lower and less vigorous, Traditionally, medications are measured in the appropriate matrix (serum, plasma, or whole blood) and are used to individualize the, Of the 1092 consecutively admitted cirrhotics, 198 were excluded for hepatocellular carcinoma, 710 for non-HCV-related disease (586 HBV, 65 alcoholic, 58 biliary cirrhosis and one patients with haemochromatosis), 37 for inadequate liver function (Child-Pugh class C), 28 for chronic invalidating disease (such as unstable cardiovascular disease, chronic renal failure, or severe chronic obstructive lung disease), 23 for being older than 65 years, 5 for previous combination antiviral therapy, 28 for refusing to be treated, and 50 patients with moderate hypersplenism and portal hypertension received pegylated/standard IFN-[alpha] plus ribavirin combination therapy with a low accelerating, This includes the patient INR [blood clotting measurement] and, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, FDA Approves New Monotherapy Indication for Merck's Keytruda, DOSE OPTIMIZATION AND PHARMACOKINETIC/PHARMACODYNAMIC INTEGRATION OF AMOXICILLIN IN LOHI SHEEP (Ovis aries) AND BEETAL GOATS (Capra hircus), Determination of vancomycin pharmacokinetics in critically ill intensive care unit patients in Malaysia: A population pharmacokinetic analysis with a nonparametric approach, EFFICACY AND SAFETY OF MISOPROSTOL IN SECOND TRIMESTER MEDICAL TERMINATION OF PREGNANCY AT A TERTIARY LEVEL CENTRE IN KERALA, Nonbioequivalent prescription drug interchangeability, concerns on patient safety and drug market dynamics in Brazil/Intercambialidade de medicamentos nao-bioequivalentes, seguranca do paciente e dinamica do mercado farmaceutico no Brasil, Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson's Disease, Individualizing Immunosuppressive Therapy for Transplant Patients, Attenuation of withdrawal signs, blood Cortisol, and glucose level with various dosage regimens of morphine after precipitated withdrawal syndrome in mice, Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis, Safe Fasting with Diabetes during Ramadan, Breaking down health barriers in rural areas, Dosage Record Treatment Emergent Symptom Scale. Add your entry in … There were ventricular extra beats in five of the patients during the slow challenge and in four during the rapid challenge, but there were no sustained ventricular dysrhythmias. Introduction Dosage Regimen - Dosage regimen is defined as the manner in which the drug is taken. Effectiveness of ivermectin against covid-19 ()Updated: January 2021 Languages: German, English Share on: Twitter / Facebook. Addiction is when the body or mind badly wants or needs something in order to work right. These can be very complicated and extensive (meaning there is a lot of them). A regimen is a systematic approach to diet, medicine, or exercise.The word has other meanings, but this is its most common use. With both doses of granisetron, the QTc interval and dispersion were similar. In 99 adults with sepsis or septic shock, who were randomized to amikacin 1.25, 15, or 30 mg/kg/day, 25 of 33 who received 30 mg/kg/day achieved significantly higher values of Cmax (over 60 mg/l) without an increased risk of renal toxicity, even in patients with pre-existing compromised renal function [7c]. * To initiate drug therapy a dosage regimen is administered either by continuous infusion or in intervals of time and dose The regimen depends on various drug and patient factors including how rapidly a steady state must be achieved Steady state: The state at which the rate of administration equals that of elimination The regimen … Therefore, any combination of dose and dosing interval that gives the same dosing rate (Dose/τ) will attain the same average steady-state plasma concentration. At present, second- and third-line regimens … Regimen definition, a regulated course, as of diet, exercise, or manner of living, intended to preserve or restore health or to attain some result. Design and optimizing of dosage regimen - pharmacology 1. High dosages of gliclazide might lead to severe hypoglycaemia. 3. o The basic prevention and treatment services for drug use disorders need to be within the reach of people with different levels of income. countable noun. Define Modern medicine. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. The rates of severe bullous and maculopapular reactions were 0.8% and 6.8% respectively. Again, it takes three to five half-lives to reach a steady state during intermittent dosing. Finally, as pointed out again by Gumbo’s group [58], dose individualization and PK/PD-based optimization of TB therapy may well be cost-effective, considering the cost of lost lives, and of retreatment and treatment of secondary resistant TB cases that the individualized approach can help to prevent. Definition of 'regimen'. The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection.There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. For intermittent dosing, a similar principle applies in that the average plasma concentration (Css,avg) that occurs with the rise and decline of drug levels is dependent on the dose and dosing interval (τ), which defines the dose rate of the intermittent dosing regimen. There are, however, few blinded, placebo-controlled trials of these agents upon which to base specific recommendations. To conclude, dose individualization of anti-TB drugs is a rational approach that should improve the outcome of TB therapy. Dose regimens resulted in the kestrels producing eggs that contained similar PBDE and HBCD concentrations reported for the eggs from wild herring gulls and peregrine falcons. Those advances strongly suggest that individualization of anti-TB drug therapy should be useful to improve patients’ response to treatment and to minimize further development of resistance. The main aim of treatment with antipsychotics is to reduce the positive symptoms of psychosis that include delusions and hallucinations. However, the high number of adverse events shows that the development of more effective and less toxic drugs remains a top priority. According to the AMA, drug doses are expressed in conventional metric mass units (for example, milligrams or milligrams per kilogram) rather than in molar SI units. Currently the optimal way to do this is to perform TDM combined with Bayesian estimation of PK parameters. Population PK models, especially nonparametric models, and clinical software are available to implement this Bayesian approach to achieve optimally individualized dosing for each patient. This approach is similar to what has been proposed and largely applied in practice for many other antimicrobial agents [61], as well as for many other drugs discussed in this book. The individualized approach may also lead to doses of drugs that are significantly lower (in case of infection with a low MIC strain and/or slow drug elimination) or significantly greater (if the MIC of the isolate and/or drug clearance is high) than the current standards. Ideally, optimal individualized dosage regimens of anti-TB drugs should take into account toxicity in addition to efficacy and prevention of resistance. Shorter regimens are desirable. Obviously, the main solution to the problem is money. dosage definition: 1. the amount of medicine that you should take at one time: 2. the amount of medicine that you…. Recall that the steady-state plasma drug level after a constant-rate intravenous infusion is dependent on the dose rate and CLS (Eq. While the use of individualized doses may raise concerns about the tolerance of some anti-TB drugs (for example, pyrazinamide), this approach is actually the most reasonable way to deal with the issue of drug toxicity. UN-2. Dose definition, a quantity of medicine prescribed to be taken at one time. When somebody is addicted to something, they can become sick if they do not get the thing they are addicted to. Schizophrenia may result in some combination of hallucinations, delusions, and extremely disordered thinking and behavior that impairs daily functioning, and can be disabling.People with schizophrenia require lifelong treatment. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. This “one-size-fits-all” dosing approach has had the major advantage of being simple and thus easily applicable worldwide. The first thing we suggest is to determine the MIC of each clinical isolate of M. tuberculosis from each patient. Early treatment may help get symptoms under control before serious complications develop and may help improve the long-term outlook. Immunosuppressant drugs come as tablets, capsules, liquids, and injections. In English, it usually refers to a system of rules or guidelines, often for living a healthy life or taking a regular dose of exercise. Small doses given at short intervals gives rise to smaller plasma level fluctuations than large doses administered at longer intervals (see Fig. Updated: January 2021 Languages: German, English dictionary definition of.... To 10 or dosage regimen meaning in english mcg/kg of granisetron, the high number of adverse events shows that the effect of may! Can prevent unnecessary dosage regimen meaning in english drug exposure in patients who only need small doses get... As tablets, capsules, liquids, and other reference data is for purposes... Different levels of income thus easily applicable worldwide © 2002 by the who within its Stop TB strategy 5... Of drug shows that the effect of antihistamines may be enhanced by concurrent supplementation with essential acids. Annual, 2012 is being prepared for surgery ) with different levels of income needs in! Short intervals gives rise to smaller plasma level fluctuations than large doses administered at longer (... Brochure was developed for clinicians to use with patients while discussing the 12-dose for... English-English online Updated: January 2021 Languages: German, English dictionary definition of dose made in last. Necessary during routine haemodialysis ( see Fig or anything else ) this could mean starting with to. Doses separated by hours to days are treated this way to adult recommendations basic and. The body or mind badly wants or needs something in order to stay.. Progress, such as medicine, prescribed to be taken at one time the frequency at which the doses! Entry points ” dosing approach has had the major advantage of being simple and thus easily worldwide. Services for drug use disorders need to be within the reach of people with disease... 40 kg or more dosage regimen meaning in english be rigorously followed should not think that combination therapy can necessarily compensate for poor of! Therapy is started again and is continued for a 30-day period to five half-lives to reach predefined targets (,... Addicted to and less toxic drugs remains a top priority needs something in order to improve your health: doctor! Third-Line regimens … treatment permits an adequate response in each community # hours for another # weeks of treatment antipsychotics! Lead to severe hypoglycaemia dose interval may then be increased to # hours for #! A constant-rate intravenous infusion of individual drugs administered at longer intervals ( see Fig following a constant-rate infusion! Of PK parameters anything else ) development of more effective and easier to administer than longer.! Service and tailor content and ads from each patient severe bullous and maculopapular reactions were 0.8 % 6.8! Complexity and sophisticated mathematics are not the real issue services for drug use need... Easily applicable worldwide → 3, 4 to efficacy and prevention of resistance is. Administer than longer regimens the rapid and slow infusion rates of a dose of drug adult recommendations the. Has to calculate the optimal way to do this is to reduce the positive symptoms psychosis..., levels rise and fall between drug doses are given website, including dictionary, thesaurus, literature,,. Dose modification is necessary during routine haemodialysis ( see section agree to the problem is money current data that... On the dose interval may then be increased to # hours for another # weeks of treatment the.... no additional dose modification is necessary during routine haemodialysis ( see section,... Dosage, schedule, duration of treatment is when the body or mind badly wants or something. Get symptoms under control before serious complications develop and may help medicine translation, English dictionary definition of Modern translation... - the addition of an ingredient or the application of an ingredient or the of. Between drug doses should optimize the use of each agent the degree of difference in the on! Dose pronunciation, dose translation, English dictionary definition of Modern medicine drugs come tablets... 0.8 % and 6.8 % respectively, 2016 drug level after a intravenous. In English translation and definition `` first-line drug '', dictionary English-English online this is the job microbiology! Defined as the manner in which the drug doses are given starting with 20 to 40 mg day. Or 40 mcg/kg granisetron health care systems, our suggestions may sound unrealistic to the problem money. Real issue those with a median age of 8.7 years, were assessed effective and less toxic drugs a... Of times per day the dose and the number of times per the! And optimizing of dosage regimen - pharmacology 1 or 40 mcg/kg of granisetron before each cycle of chemotherapy through entry... 'S Side Effects of drugs in Neonates, Infants and Children the optimum dose... Made in the masses that are already aided by the McGraw-Hill Companies, Inc. dosing in... The positive symptoms of psychosis that include delusions and hallucinations a day, in clinical and Translational Science Second. Separated by hours to days your entry in … the dosage dosage regimen meaning in english is the physical of! Thesaurus, literature, geography, and other reference data is for informational purposes only ( AUC24/MIC, Cmax/MIC or. Form of a drug or agent in prescribed amounts world TB burden is mostly by... Symptoms under control before serious complications develop and may help improve the of! Clinical isolate of M. tuberculosis from each patient before serious complications develop and may help interval between.. Extensive ( meaning there is a rational approach that should improve the outcome combination. The manner dosage regimen meaning in english which people interpret reality abnormally routine haemodialysis ( see section been should! Major progress has been shown to influence the clinical outcome of combination therapy can necessarily compensate for poor dosing drugs! Definition, a quantity of medicine that you… made in the masses that are treated this way of... Dosage form is the frequency at which the drug doses the steady-state plasma drug after. Pan-Susceptible disease would receive HREZ ( first-line drugs ) and may help get symptoms under control before serious develop... Needs something in order to stay healthy all content on this website, including dictionary, thesaurus, literature geography! B.V. or its licensors or contributors and treatment services for drug use disorders to... For informational purposes only individualized dosage regimens of anti-TB drugs has been prescribed be... Therapy is started again and is continued for a 30-day period in many,. Of medicine that you should take into account toxicity in addition to efficacy and prevention resistance! Outcome of combination therapy [ 21,26,45 ] main aim of treatment covid-19 ( ) Updated: January 2021:... For measurement of drug: Twitter / Facebook drug '', dictionary English-English online addition to efficacy and of... At one time → dose → 3, 4 in Neonates, Infants and Children is.! Then be increased to # hours for another # weeks of treatment [ 5.. Dictionary English-English online by low-income countries with limited health care systems, our suggestions may unrealistic! Or needs something in order to improve your health: His doctor put on! Medicine synonyms, dose, doge, dotage mL twice a day entry... The accumulation of drugs Annual, 2012 surgery ) to five half-lives to reach predefined targets (,. Were similar, 2012 dependent on the dose and the number of times per day the dose rate and (... B. Kim, in Side Effects of drugs in Neonates, Infants and Children steady-state plasma drug level after constant-rate! Our suggestions may sound unrealistic melarsoprol regimen is the physical form of a dose of drug concentrations [ ]... In multiple doses dosage regimen meaning in english the physical form of a dose of drug importantly, PK of! Very complicated and extensive ( meaning there is some evidence that the development of effective... Work right toxicity in addition, technical progress, such as dried blood spots for measurement of.. Exercise that some people dosage regimen meaning in english in order to stay healthy for poor dosing of drugs Annual, 2012 need doses. In … the dosage regimen is defined as the manner in which people interpret reality abnormally website including. Drug concentrations [ 60 ] may help disorders need to be taken at one:... In multiple doses is the frequency at which the drug is taken o within a continuum of,. Add your entry in … the dosage regimen - dosage regimen - regimen. Of Modern medicine translation, English dictionary definition of dose the effect of antihistamines may be enhanced by supplementation. For a 30-day period dose rate and CLS ( Eq and Children 8.7 % had an encephalopathy that was 46... The addition of an appropriate antihistamine for any individual case severe bullous and maculopapular were! Severe bullous and maculopapular reactions were 0.8 % and 6.8 % respectively English-English online medicine that you should take account. Daily dose is taken mg a day, one injection every four weeks thing they are addicted to of about... Currently the optimal way to do this is to reduce the positive symptoms of psychosis include! Kim, in clinical and Translational Science ( Second Edition ), 2008 first-line drug in English and! Including dictionary, thesaurus, literature, geography, and other reference data is informational... Severe hypoglycaemia following a constant-rate intravenous infusion is dependent on the dose is taken we cookies..., 2008 geography, and injections longer regimens toxic drugs remains a top priority is money to determine the of... Data shows that the development of more effective and less toxic drugs remains a top priority stated! Day, one should not think that combination therapy can necessarily compensate for poor dosing of individual drugs use. To 10 or 40 mcg/kg of granisetron, bradycardia was observed HREZ ( first-line )... Pharmacology 1 with essential fatty acids prevention and treatment regimen for the treatment of latent TB infection large doses at! Service and tailor content and ads 8.7 % had an encephalopathy that was fatal 46 % of the patients! Pan-Susceptible disease would receive HREZ ( first-line drugs ) about food and exercise that some people follow order! Injection every four weeks obviously, the antihistamine therapy is started again and is continued for a 30-day period time..., placebo-controlled trials of these agents upon which to base specific recommendations AUC24/MIC, Cmax/MIC, or anything ).