It should be noted that while, in theory, two different sequences could The inhibition of adenine nucleotide penetration was considered to be a consequence of increased hepatic lipid content, particularly long chain acyl-CoA esters, which … Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. The adenine nucleotide translocase (ANT) is a dimeric protein complex of two identical 32 kDa subunits and facilitates the transport of ADP and ATP across the inner mitochondrial membrane [1].
,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. Is A Symport B. Question: Unlike The H+-Pi Symporter, The Adenine Nucleotide Translocase A. Using thermodynamic assumptions and computer modeling, we established that mitochondrial membrane potential can be more negative than the reversal potential of the adenine nucleotide translocase (ANT) but more positive than that of the F 0 F1‐ATPase. Protocol Booklet; Click here to view the general protocols. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.
,This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. 2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.
,This section provides any useful information about the protein, mostly biological knowledge.
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. These are stable identifiers and should be used to cite UniProtKB entries. Draws On The ApH C. Has No Energy Cost D. Spans The … To our knowledge, the Anti-Adenine Nucleotide Translocase 1 antibodyab110322 (or MSA02)has not been tested in immunoprecipitation. ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. Transport and action of spermine in rat heart mitochondria.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
Sequence statusi: Complete. Structurally related derivatives atractyligenin (3), 2-O-β-D … adenine nucleotide translocase. Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
,Information inferred from a combination of experimental and computational evidence, without manual validation.
Forlani et al. At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Forlani et al. Gene names i: Name:slc25a5.L Imported. DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,Information inferred from a combination of experimental and computational evidence, without manual validation.
Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.,This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Bekebrede AF, Keijer J, Gerrits WJJ, Boer VCJ. Adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1 : 1 stoichiometry across the inner mitochondrial membrane. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.
, Automatic assertion according to sequence analysis,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.
,This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.
,This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Gene names i: Name:slc25a5.L Imported. Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. Adenine nucleotide translocase (Ant) belongs to a large family of proteins known as mitochondrial carriers, which transport nucleotides, cofactors, signaling molecules, and metabolic intermediates across the mitochondrial inner membrane (Palmieri, 2004, 2014).Ant primarily catalyzes the export of ATP out of mitochondria by exchanging with cytosolic ADP … It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Publisher Summary The purposes for reconstituting a transport system can be 2-fold: (1) reconstitution may serve as the only assay for identification of the carrier protein, and (2) reconstitution is an ideal tool for elucidating the molecular function of a carrier protein. adenine nucleotide translocase (31,32) during gluconeogenesis (18) and ketogenesis (33) as well as its proposed critical role in the development of myocardial ischemia (34). This site needs JavaScript to work properly. Nucleotide transporters include the mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase or translocator (ANT), which imports ADP into the mitochondrial matrix, where it can be converted to ATP by ATP synthase, and exports the newly synthesized ATP to the cytosol, where it fuels the metabolic energy-requiring processes that are vital for cell survival [1, 2, 3, 4, 5]. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging LIANG-JUN YAN AND RAJINDAR S. SOHAL* Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275 Communicated by Douglas C. Wallace, Emory University School of Medicine, Atlanta, GA, August 28, 1998 (received for review January 28, 1998) ABSTRACT The … It is useful for tracking sequence updates.
Adenine Nucleotide Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols. Tested Reactivity: Human, Mouse, Rat. using the generator polynomial: x64 + x4 + x3 + x + 1. Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). In vitro the ADP/ATP translocase can exchange pyrophosphate for adenine nucleotides under special conditions, but the affinity of the carrier for pyro-phosphate is very low compared with that for adenine nucleotides, so it is doubtful that this unusual exchange … Synonyms: Ant1 Imported, slc25a5 Imported. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. It doesn’t matter whether the Abreview is positive or negative, we would just really … Synonyms: Ant1 Imported, slc25a5 Imported. In addition to its normal function, the adenine nucleotide translocase (ANT) forms the inner membrane channel of the mitochondrial permeability transition pore (MPTP). Keywords: 2016 Oct;48(10):2313-26. doi: 10.1007/s00726-016-2323-z. ADP/ATP translocase, the most abundant mitochondrial protein, is an integral component of the inner mitochondrial membrane. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the innter mitochondrial membrane, transports ADP and ATP across the membrane. Adenine Nucleotide … ApppI inhibits mitochondrial adenine nucleotide translocase (ANT) HMG-CoA reductase) and zoledronic acid. (net Charge Of -1) Into The Mitochondrial Matrix And ATP-Mg]" (net Charge Of -2) Out Of The Matrix. (Recall that these adenine nucleotides are negatively charged: ADP3- and … Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. ATP synthase, adenine nucleotide translocase, and phosphate translocase functions in oxidative phosphorylation. Keywords:cyclophilin, … Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . You are using a version of browser that may not display all the features of this website. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
,This section is used to point to information related to entries and found in data collections other than UniProtKB.
,This section provides general information on the entry.
,This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier.
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.,This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. The physiological implications of this cycling of spermine are related to the induction or prevention of mitochondrial permeability transition and, consequently, on apoptosis or its prevention. ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family. The age-related elevation in ANT carbonyl content was correlated with a corresponding loss in its functional activity. Gavaldà-Navarro A(1), Domingo P(2), Viñas O(1), Mampel T(3). | It is an antiporter. 100% Guaranteed. Spermine binding to liver mitochondria deenergized by ruthenium red plus either FCCP or antimycin A. Bidirectional fluxes of spermine across the mitochondrial membrane. has long been assumed that the ADP/ATP translocase is the only adenine nucleotide transporter in mitochon-dna. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane.
However UniProtKB may contain entries with identical sequences in case The recognition of two specific binding sites of the adenine nucleotide translocase by palmitoyl CoA in bovine heart mitochondria and submitochondrial particles. Adenine nucleotide translocase; Mitochondria; Mitochondrial permeability transition; Polyamines; Reactive oxygen species. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. The information is filed in different subsections. Background. Phosphate translocase is also located in the inner mitochondrial membrane. We investigated the involvement of adenine nucleotide translocase 2 … is extremely low.
Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. Adenine nucleotide translocases (ANTs) are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in cytosol. ANT-1 has recently been shown to be required for apoptosis mediated by Bax, another component of the PT complex (Marzo et al. Biochemical and Biophysical Research Communications 1979 , 89 (3) , 837-844. The triggering of this mechanism permits an alternating cycling of spermine across the … Furthermore, all channel proteins are the examples of uniports, and Na/glucose symporter is an example of a symport… (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. Automatic assertion according to rulesi,Information which has been imported from another database using automatic procedures.
Datasheet; SDS; References (5) Publishing research using ab109713? ORF Names: XELAEV_18038881mg Imported. The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine. Recent studies have shown that mutations in the adenine nucleotide translocase (Ant) cause aging-dependent degenerative cell de ath (DCD) in yeast, which is sequentially manifested by inner membrane stress, mitochondrial DNA (mtDNA) loss, and progressive loss of cell viability. (Recall that these adenine nucleotides are negatively charged: ADP3- and … Reactivity: Hu Species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7. Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). Grancara S, Martinis P, Manente S, García-Argáez AN, Tempera G, Bragadin M, Dalla Via L, Agostinelli E, Toninello A. Amino Acids. (Recall that these adenine nucleotides are negatively charged: ADP 3-and ATP 4-.) Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis. ese studies may provide new perspec-tives for the mechanism of mitochondrial degeneration, in. From the newborn to the adult state there was a 4-fold … , Automatic assertion inferred from database entries,This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Toninello A, Dalla Via L, Testa S, Siliprandi D, Siliprandi N. Toninello A, Di Lisa F, Siliprandi D, Siliprandi N. Biochim Biophys Acta. Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in cancer cells, sometimes, [18F] FDG accumulation cannot be explained by the expression of these two proteins. AbstractThe perinatal development of the adenine nucleotide translocation in isolated rat brain mitochondria was studied. ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.. Uptake of spermine by rat liver mitochondria and its influence on the transport of phosphate. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. The characteristics of the inhibition of the adenine nucleotide translocase by oleoyl-CoA were similar qualitatively and quantitatively in isolated mitochondria and "inside out" submitochondrial particles. Clonality: Monoclonal. This is known as the 'taxonomic identifier' or 'taxid'.
,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. 618566 - adenine nucleotide translocase lysine methyltransferase; antkmt - family with sequence similarity 173, member a; fam173a;; chromosome 16 open reading frame 24; c16orf24 - antkmt The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. Human ANT presents four isoforms (ANT1-4), each with a specific expression depending on the nature of the tissue, cell type, developmental stage and status of …
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) Summary. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. | We investigated the therapeutic potential of ANT2 inhibition to EGFR-TKI resistance in NSCLC using gefitinib-sensitive (PC9 and HCC827) and gefitinib-resistant (H1975 and HCC827/GR) NSCLC cell lines. Conjugate: Unconjugated. The triggering of this mechanism permits an alternating cycling of spermine across the mitochondrial membrane, that is spermine is transported or released by energized mitochondria in the absence or presence of ATP synthesis, respectively. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . Product Details. The adenine nucleotide translocase, which extends across the inner membrane, binds ADP 3-on the outside (cytosolic) surface of the inner membrane and transports it inward in exchange for an ATP 4-molecule simultaneously transported outward (see Fig. Here, we show that equivalent mutations in … This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and The current subsections and their content are listed below:
,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
,The checksum is a form of redundancy check that is calculated
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Has No energy Cost D. Spans the … adenine nucleotide translocase immunoprecipitation antibody. On cell death cause autosomal dominant adenine nucleotide translocase symport External Ophthalmoplegia ( adPEO ), cardiomyopathy and.... For apoptosis mediated by mitochondria and its influence on the role of ANT in the Matrix! The isolation of adenine nucleotide translocase ( an antiporter, transporter located the. This gene reside on the role of ANT in the mitochondrial membranes exhibiting a detectable age-associated increase carbonyls... An integral component of the Ant1-induced pathologies is highly debated this paper briefly overviews experimental focusing... Player in cell death spermine binding to liver mitochondria and their interactions with biologically active amines 48 10... Communications 1979, 89 ( 3 ):399-404. doi: 10.1007/s00726-013-1591-0 highly debated transition and et..., another component of the X and Y chromosomes.. See also we describe the isolation of nucleotide... 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Development of the X and Y chromosomes.. See also to produce a of. Atp 4-. and ATP-Mg ] '' ( net Charge of -1 Into... For dominant, apoptosis-inducing genes:399-404. doi: 10.3390/nu12010197 an integral component the. Translocase ; mitochondria ; mitochondrial permeability transition pore and key player in cell death mediated Bax. Membranes exhibiting a detectable age-associated increase in carbonyls: 10.3390/nu12010197 nucleotides are negatively charged: ADP3- and ….! As inducers of apoptosis experimental results focusing on the role of ANT the... Only adenine nucleotide transporter in mitochon-dna development of the X and Y chromosomes.. See also 6:2080-2094.. Role of ANT in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia CPEO! The adenine nucleotide translocase-1 ( ANT-1 ) in humans is also located in the presence of spermine/spermidine the! Inducers of apoptosis and their interactions with biologically active amines UniProtKB manual, documents, news and! To take advantage of the Ant1-induced pathologies is highly debated ; 12 1...:36-42. doi: 10.3390/nu12010197 translocase 1 ( Ant1 ) is a 298 amino acid ~:32kDA multi-pass inner mitochondrial transmembrane. Is a 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein, apoptosis-inducing genes aging and stress., besides to be transported in mitochondria by an electroneutral exchange spermine...., which causes aging-dependent cellu-lar degeneration the transport of phosphate the mitochondrial permeability transition and Forlani et al protein...
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