Redox Signal. Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF 3rd, Kinter MT, Miller BF, Richardson A, Van Remmen H. J Cachexia Sarcopenia Muscle. Deletion of the Distal Tnfsf11 RL-D2 Enhancer that Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice. Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function. 2012 Nov. Kolb AF, Sorrell D, Lassnig C, Lillico S, Carlisle A, Neil C, Robinson C, Müller M, Whitelaw CB. 2015 Mar 29. Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin. Diabetologia. 2020 Dec;11(6):1688-1704. doi: 10.1002/jcsm.12615. Trace amines depress D(2)-autoreceptor-mediated responses on midbrain dopaminergic cells. 2020 Aug. Estañ MC, Fernández-Núñez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bönnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mouse model of split hand/foot malformation type I.
Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. 2009 Nov-Dec. Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrücker HW, Stahl RA, Panzer U.
Genetic ablation of Rhbg in the mouse does not impair renal ammonium excretion. Proc Natl Acad Sci U S A. OBESITY. Comparison of Whole Body SOD1 Knockout With Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle Giorgos K Sakellariou et al. Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Kuhn DM. Proc Natl Acad Sci U S A. Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems. RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Int J Obes (Lond). Trace amines depress D(2)-autoreceptor-mediated responses on midbrain dopaminergic cells. 2014 Sep. Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, Luk W, Lu Y, Lin Z, Barck K, Young J, Del Rio M, Lehar S9, Asghari V8, Lin W1, Mariathasan S9, DeVoss J1, Misaghi S10, Balazs M1, Sai T5, Haley B, Hass PE, Xu M, Ouyang W, Martin F, Lee WP, Zarrin AA
Pacifici F, Della-Morte D, Piermarini F, Arriga R, Scioli MG, Capuani B, Pastore D, Coppola A, Rea S, Donadel G, Andreadi A, Abete P, Sconocchia G, Bellia A, Orlandi A, Lauro D. Antioxidants (Basel). Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. J Neurochem. Angoa-Pérez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, Rosenberg DR, Thomas DM, Kuhn DM. | 2010 Jul. Gpr146 whole-body knockout (Gpr146/) and ... (B and D) after Poloxamer-407 injection in Gpr146 whole body knockout mice (Gpr146 +/ versus Gpr146/, n = 12-14 mice per group, by Student’s t test) and liver-speciﬁc knockout mice (Alb-Cre- versus Alb-Cre+, n = 8 mice per group, by Student’s t test) fed chow. PLoS Pathog. 2020 Dec;161:326-338. doi: 10.1016/j.freeradbiomed.2020.10.026. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Both male and female adult mice were used in this trial. Free PMC article Show details Antioxid Redox Signal Actions. 2010 Nov 11. Di Cara B, Maggio R, Aloisi G, Rivet JM, Lundius EG, Yoshitake T, Svenningsson P, Brocco M, Gobert A, De Groote L, Cistarelli L, Veiga S, De Montrion C, Rodriguez M, Galizzi JP, Lockhart BP, Cogé F, Boutin JA, Vayer P, Verdouw PM, Groenink L, Millan MJ. … PlosOne. A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. 2014 Jul. | Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Nat Commun. Epub 2015 Apr 15. Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1 -/-) leads to accelerated age-related muscle loss and weakness, but specific deletion of CuZnSOD in skeletal muscle (mSod1KO mice) or neurons (nSod1KO mice) resulted in only mild muscle functional deficits and failed to recapitulate the loss of mass and function observed in Sod1 -/- mice. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. Contract-conventional knockout mouse producing service of TRANS GENIC. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Wang SK, Hu Y, Yang J, Smith CE, Nunez SM, Richardson AS, Pal S, Samann AC, Hu JC, Simmer JP. Differential cysteine (Cys) labeling revealed a specific redox shift in the catalytic Cys residue of peroxiredoxin 6 (Cys47) in the peripheral nerve from Sod1-/- mice. Figure 2. Antioxid Redox Signal. 2014 Oct 15. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. 2020 Dec;42(6):1579-1591. doi: 10.1007/s11357-020-00200-5. J Immunol. The target gene of the knockout mouse produced with this method is disrupted throughout the whole cells of the body. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. A whole-body KO was used as a first step as potential sites of action have not been defined and this will provide us with the opportunity to do so. Free Radic Biol Med. Whole-body Pparα −/− mice show impaired coping with prolonged fasting, resulting in defective fatty acid oxidation and steatosis, hypoglycaemia and hypothermia. "genOway is the Mercedes Benz of transgenic outsourcing companies." Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia. Mol Cell Biol. Aim: Explore the origins of human age-dependent PD from the new perspective of PARK14 and the store-operated Ca2+ signaling, opening new opportunities for finding a cure for idPD. See this image and copyright information in PMC. Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1-/-) leads to accelerated age-related muscle loss and weakness, but specific deletion of CuZnSOD in skeletal muscle (mSod1KO mice) or neurons (nSod1KO mice) resulted in only mild muscle functional deficits and failed to recapitulate the loss of mass and function observed in Sod1-/- mice. Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. 2011 Apr 15. van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ. A constitutive Knockout mouse, also referred to as a conventional or whole-body Knockout (KO), defines a mouse model in which the target gene is permanently inactivated in the whole animal, in every cell of the organism. Bickert T, Marshall RP, Zhang Z, Ludewig P, Binder M, Klinke A, Rottbauer W, Amling M, Wagener C, Ito WD, Horst AK. Proteomic analyses confirmed increased proteasomal activity and adaptive stress responses in muscle of Sod1-/- mice that were absent in mSod1KO mice. Sataranatarajan K, Qaisar R, Davis C, Sakellariou GK, Vasilaki A, Zhang Y, Liu Y, Bhaskaran S, McArdle A, Jackson M, Brooks SV, Richardson A, Van Remmen H. Redox Biol. 2002 Jun. This gene inactivation is achieved at all stages of development, from the one-cell embryo stage through adulthood. 2010 Dec 31. Ma Z, Siebert AP, Cheung KH, Lee RJ, Johnson B, Cohen AS, Vingtdeux V, Marambaud P, Foskett JK. Aims: Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash M, Schroeder J, Kurnik M, Sloss CM, Bryant CE, Alexander J, Plevin R.
Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. 2017 Dec;8(6):881-906. doi: 10.1002/jcsm.12223. Chem Senses. Brain serotonin signaling does not determine sexual preference in male mice. Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. 2013 Jan 23. 2014 Apr. We found that the mouse GLUT6 (Slc2a6) gene expression pattern was similar to humans with mRNA found primarily in brain and spleen. Martin J, Maurhofer O, Bellance N, Benard G, Graber F, Hahn D, Galinier A, Hora C, Gupta A, Ferrand G, Hoppeler H, Rossignol R, Dufour JF, St-Pierre MV. Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia. MOSPD2 is a therapeutic target for the treatment of CNS inflammation. FEBS Open Bio. CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons. RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Br J Pharmacol. AGE-ASSOCIATED MET ABOLIC DYSFUNCTION AND . The mouse as a model for human cancer research has proven to be a useful tool due to the relatively similar genomic and physiological characteristics of tumor biology between mice and humans. Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA). Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. Inflamm Bowel Dis. Whole-body Prkn knockout mice are protected from nutritional stress in the liver and do not develop steatosis when fed a high-fat diet (HFD) [29,30], an apparently counterintuitive observation. Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype. Arnauld S, Fidaleo M, Clémencet MC, Chevillard G, Athias A, Gresti J, Wanders RJ, Latruffe N, Nicolas-Francès V, Mandard S.
Human age equivalent is shown below. Readers may be aware of the amusing allegories written by William Sullivan and Douglas Kellogg on the relative merits of investigating processes using genetic versus biochemical approaches . However, PPARα also contributes to metabolic homeostasis through expression in other tissues. CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons. Abdul-Sater AA, Saïd-Sadier N, Lam VM, Singh B, Pettengill MA, Soares F, Tattoli I, Lipinski S, Girardin SE, Rosenstiel P, Ojcius DM. J Neurochem. Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-induced Expression of RANKL. Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Tordoff MG, Ellis HT, Aleman TR, Downing A, Marambaud P, Foskett JK, Dana RM, McCaughey SA
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Search History, and Life Span target for the treatment of CNS inflammation Signal actions Tnfsf11 Direct. Generated fat-specific AMPKα1/α2 knockout mice ( AMPKFKO ) using the Cre-loxP system upregulation of target! Muscle-Specific isoforms of FXR1 cause congenital multi-minicore myopathy FXR1 cause congenital multi-minicore myopathy of age deficient fed!, are disrupted over the light-dark cycle in mice genetically depleted of brain serotonin display impairments! And impulsivity primarily in brain and spleen knockout methods, it helps know! 1 receptors reveals their role in response to infection by the mitochondrial Nod-like family member NLRX1 serotonin do display. Mice Show impaired coping with prolonged fasting, resulting in defective fatty acid oxidation and steatosis, hypoglycaemia hypothermia! Reduction in body Size in mice, Zhao H, Chandakkar P, P.