common laboratory animals pdf

0000008239 00000 n 0000002911 00000 n endobj *{~��ƅ �m��:?R��n��@��8�� >��+l��aq?��}��?��+�D�W��W֙�'��^~�@�,|�b�X�,��\=h��d�C��_{�b�4�S9��E��1�[�F�� Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF. 0000002890 00000 n Standardized nomenclature for transgenic animals. %PDF-1.2 %�� About this journal. Sources of animals Under the 1986 Act the following commonly-used species that are bred for laboratory use: mouse, rat, guinea-pig, hamster, rabbit and primate must be obtained from designated breeding or supply establishments. From: Lab Animal. <> These usually have been preserved by embalming, and one or more parts of the vas-cular system have been injected with a colored material to facilitate identiﬁ cation of the vessels. 9. Study in a typical gross anatomy laboratory is based primarily on dissection of animal cadav-ers. Proper handling of laboratory animals goes a along way to ensure reproducible results are obtained. The domestic mouse, Mus musculus and related subspecies (see Mice and Rats as Laboratory Animals), is popular as a mammalian research model because of its small size, adaptability, docility, low husbandry costs, fecundity, well-defined health and genetic backgrounds, and relative ease of genetic manipulation.The development of genetic engineering techniques of inserting … 0000006282 00000 n The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses … 86 87. INTRODUCTION Selection of animal model Use of an animal phylogenetically closer to man Use of an animal in which the process under investigation is as close as possible 2. The Clinical Chemistry of Laboratory Animals 3rd Edition PDF. This handbook attempts to provide a basic guide to anaesthesia for research workers and animal technicians. 0000003696 00000 n <>stream laboratory animals according to the animal welfare and ethical norms. Animals used for laboratory research or teaching purposes at the University of Montana (UM) include mice, rats, guinea pigs, rabbits, hamsters, and birds. BIOLOGICAL NAMES • Genus: which have common characteristics and which can be divided into subordinate kinds. The Welfare of Laboratory Animals PDF.. <> It is not intended to be a comprehensive text on animal anaesthesia, but concentrates on those areas that are of greatest practical importance when anaesthetizing laboratory animals. Analgesics 5. endobj The international journal of laboratory animal science, technology, welfare and medicine, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the care and use of animals in biomedical research. A zoonotic disease is any disease that may be transmitted from an animal to a human under natural conditions. It is estimated that anywhere from 10% to 44% of animal care workers will develop allergic symptoms to the animals. Laboratory Animals 1. endobj Laboratory Animals. Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. Wildlife species used as research s… 0000001354 00000 n <>/Rotate 90/Parent 5 0 R/Annots[]/MediaBox[0 0 612 792]/Contents 6 0 R/Type/Page>> Recordkeeping 8. Anesthetics 4. One of the most common health risks in the research animal setting is allergic reaction to lab animals. H��TMS�0�{��AG��U}�:��4��2�� :6Mb��we%��d��C�+�{��vu��c�J��K�p�26!L�t�;d�'D .�_8_: �k|6�6��;�b)ÿ�7��t��|8��n�3G�芙��U��~F\�½��ʙ��]N�ZǲU�!�2 y�P�Y�>n�V'��I�"�U+�'\��>� 攲I�i�ҷ�? VETERINARIANS TREATING common farm and companion species can use a wide range of drugs with regulatory approval. Source: Adapted from Formulary for Laboratory Animals, Hawk, Leary, and Morris 2005. Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study.This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. 0000004511 00000 n 0000000927 00000 n Blood Collection Sites and Methods The following are frequently used sites for survival blood sampling from common laboratory animal species. x��][�$�q��>Zy�+˖bgV��9��y'_��XX Q��A)��T�V�fuϬ,ـDM�R,?֍~��wq1��/��_A�xRnI��J-�b<=��z�a��>�?_}{�o�7.0��6��P�� A-quޜ߾�"��_Ҫ��14IF�t�E�:��ZT��C��{H��:�3k��[�9�Ca�-��z�.��7�&��G�.ںp~��}G��:N>��^CA�:��]6W��Z��B-c:��. Introduction Laboratory animals are used for different studies It may include bioassay, preclinical studies etc. 0000001951 00000 n 0000001597 00000 n In many clinical situations, laboratory animal veterinarians do not <> Table of Contents 1. ), and the Animal Welfare Act (Public Law 89-544). 0000002783 00000 n 0000009138 00000 n A report of the Institute of Laboratory Animal Resources Committee on Rat Nomenclature. H�c```�k��&J]`p��P}j��`qfE�Z��ƆY��zY\y��H�~Sq�Y�� ޭ2SȽ(��(��pF��R끖� �:B��ԀFa��@&�1�� (�X\@�Y�� .I��A,"��!밆�qjc�s��x]�=�:8L xS�f2�T?��)(��ƴ�uZ�K�%�XH� ]�Hs�8L� the animal is anemic (below the normal PCV range for the species), or if the hemoglobin concentration is less than 10 g/dL, it is not safe to remove the volumes of blood listed above. 3 0 obj 0000009117 00000 n The aim was to refine administration procedures and improve animal welfare and science. 1. of . 0000001735 00000 n Collection of blood from laboratory animals is frequently necessary for a variety of experimental uses including determination of pharmacokinetics, antibody production, clinical pathology evaluation, etc. The focus %�� Provides information on blood sampling techniques for many common species to help laboratory staff remove blood from animals in the most humane and efficient way. Dogs and cats must be obtained from designated breeding establishments. The prevention or minimization of animal pain, distress, or discomfort by the proper use of tranquilizers, anesthetics, and analgesics is scientifically and ethically essential to the humane care, use, and treatment of research animals. April 1967 - December 2020 Select an issue. Blood sample collection in small laboratory animals, J Pharmacol Pharmacother, 2010 Jul-Dec; 1(2); 87-93. Laboratory animals are animals used for research purposes for developing and testing medicines and vaccines for humans and other animals. It is organized into five chapters that cover the subject areas of 1) key defining concepts, including applicability, a brief review of the ethical principles in the … 0000007266 00000 n 0000008218 00000 n 6 0 obj 1992b. 1 0 obj 0000007164 00000 n �y�%�$^�M��A�B��]*�L�;G��v��)`�셗"��s��82��5�Y�XGVP�I?8��zZ�yY߻9n�e��71�7U;��W-�Cm�Fmʳvm��(�{0�Xi�� ;~]|>g�*>)��O�_�O��ԋDf�4PY 1ka��ڏ�{RXB�&�ta�-k�蓶�Cȹ �!l�n*΍��=U? 0000009824 00000 n 2020 2020 Volume 54 Issue 6, Current Issue December 2020 , pp. Common Sites for Blood Collection: �]�h��L�X�"�/p��a��shR�L��'�&�úD�. 0000001375 00000 n 5 Last Revised December 20, 2016. It is the responsibility of Principal Investigator (PI) to educate their staff on zoonotic diseases of the animals that they are using in their research or teaching activities. Laboratory/Research Skills for Science Resume List of skills to assist with resumes, cover letters and interviews Animal Care Handle and restrain Weigh animals Breed various species Clean cages Administer injections Prepare special diets Anesthetize Maintain and evaluate animal records Prepare for sterile surgical procedures Laboratory Animals (2006) 40 , 217 235 REVIEW ARTICLE Correspondence: J P Balcombe. <> 59 0 obj << /Linearized 1 /O 61 /H [ 982 393 ] /L 79810 /E 10068 /N 9 /T 78512 >> endobj xref 59 29 0000000016 00000 n 0000006303 00000 n NRC (National Research Council). List of Issues View. Email: jbalcombe@pcrm.org. 0000005391 00000 n {.s��|��-2��LPȋ��͛�ο)� Wz�,�{a��"��M�ɿ��q}��b�͞ʬ.�l7��&��)�!z�H�tWca��"�gQj��7< endstream endobj 69 0 obj 716 endobj 70 0 obj << /Filter /FlateDecode /Length 69 0 R >> stream Browse by year. Read chapter DISEASES OF LABORATORY ANIMALS: Handbook of Laboratory Animals... Login Register Cart Help. The paper covered the most commonly used routes in common laboratory species. 525-607 Issue 5, October 2020 , pp. 35, 1-41. Animal Care and Use Committee Page . Laboratory animals have been successfully trained to perform various husbandry or clinical tasks, including moving to a new part of an enclosure (Veeder et al., 2009), presenting a body part for an injection or another procedure (Priest, 1991; From: Animal Models for the Study of Human Disease (Second Edition), 2017. endobj Definition, nomenclature, and conservation of rat strains. Monitoring 7. • Guidelines for anesthesia and analgesia in laboratory animals; University of California. Handling of laboratory animals and ethics 10th to 11th Novomber, 2016 Laboratory Animal Resources Section ICAR- Indian Veterinary Research Institute Izatnagar, Bareilly-243 122(U.P), India Training Program on Background 2. In addition, an estimated 10% of workers will eventually develop occupation-related asthma. ;��GD�� ]�P�;��/��ַ�J��)�Ojb2F�5�� 1¼��0��ap�n��Sp��F((��&��}�E�U�� ҸirW�ƣy6�b��,��-sgJg7o��ge]. 0000007346 00000 n 0000000982 00000 n Healthy and well being of lab. 0000005412 00000 n Blood Sampling in Sheep ( pdf … Common laboratory animal MARTIN JACOB 1ST YR M.PHARM Department of pharmacology Shree devi college of pharmacy manglore 2. Laboratory Animals: All Issues - Laboratory Animals. endobj trailer << /Size 88 /Info 58 0 R /Root 60 0 R /Prev 78502 /ID[] >> startxref 0 %%EOF 60 0 obj << /Type /Catalog /Pages 57 0 R >> endobj 86 0 obj << /S 202 /T 290 /Filter /FlateDecode /Length 87 0 R >> stream Blood may be collected from animals which are to survive the procedure or at sacrifice as a terminal event. E.g. 0000001842 00000 n • Research animals must be used in a responsible manner. H�}T�r�0�{��;�*��#M�qRצ]䱐A1j ��I��-��#JC�*US��~/�� ًC��rp� I�� ?�F�R֖��C�j1�Q[{��RT�+a2�H8��r�}1$�N� F ��0y(�VSm�&1��5��[� }��t�1 �r�@��ۆ��:��p3Ȭ8�(��jT=��?��#�C�5��z�ޙM��4��@-. Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals 3rd Edition continues as the most comprehensive reference on in vivo animal studies. OLAW and APHIS: Common Areas of Noncompliance STEPHEN POTKAY, VMD AND WILLIAM R. DEHAVEN, DVM OLAW’s Compliance Oversight: Noncompliance with PHS Policy Stephen Potkay, VMD The welfare of animals used in research has been a concern of the Public Health Service (PHS) since the mid-1900s1. 5 0 obj However, there is a growing body of literature on environmental-enrichment strategies for many of the common laboratory animal species, and the Guide (NRC 1996a) provides an impetus for institutions to evaluate and incorporate enrichment measures into their animal care and use program for all species where appropriate. ,c��s��L�S]�=�� Ib endstream endobj 87 0 obj 280 endobj 61 0 obj << /Type /Page /Parent 57 0 R /Resources 62 0 R /Contents [ 68 0 R 70 0 R 72 0 R 74 0 R 76 0 R 80 0 R 82 0 R 84 0 R ] /Thumb 36 0 R /MediaBox [ 0 0 598 846 ] /CropBox [ 0 0 598 846 ] /Rotate 0 >> endobj 62 0 obj << /ProcSet [ /PDF /Text ] /Font << /F2 77 0 R /F9 63 0 R /F10 64 0 R /F11 66 0 R >> /ExtGState << /GS1 85 0 R >> >> endobj 63 0 obj << /Type /Font /Subtype /Type1 /Name /F9 /Encoding 65 0 R /BaseFont /Times-Roman >> endobj 64 0 obj << /Type /Font /Subtype /Type1 /Name /F10 /Encoding 65 0 R /BaseFont /Times-Italic >> endobj 65 0 obj << /Type /Encoding /Differences [ 1 /Agrave /Egrave /Igrave /Ograve /Ugrave /agrave /egrave /igrave /ograve 11 /Aacute /Eacute /Iacute /Oacute /Uacute /Yacute /aacute /eacute /iacute /oacute /uacute /yacute /Acircumflex /Ecircumflex /Icircumflex 27 /Ucircumflex /acircumflex /ecircumflex /icircumflex /ocircumflex 128 /ucircumflex /Atilde /Ntilde /Otilde /atilde /ntilde /otilde /Adieresis /Edieresis /Idieresis /Odieresis /Udieresis /Ydieresis /adieresis /edieresis /idieresis /odieresis /udieresis /ydieresis /Aring /aring /Ccedilla /ccedilla /Scaron /Zcaron /scaron /zcaron /Eth /eth /Thorn /thorn /Ocircumflex /minus 209 /trademark /copyright /logicalnot /registered 214 /brokenbar /degree /plusminus /twosuperior /threesuperior /mu /onesuperior /onequarter /onehalf /threequarters /multiply ] >> endobj 66 0 obj << /Type /Font /Subtype /Type1 /Name /F11 /Encoding 65 0 R /BaseFont /Times-Bold >> endobj 67 0 obj 686 endobj 68 0 obj << /Filter /FlateDecode /Length 67 0 R >> stream Note: If the amount of blood volume removed is 7.5% of total blood volume, allow 1 week recovery; if amount removed is 10%, allow 2 weeks recovery; if amount removed is 15%, allow 4 weeks recovery. laboratory animals 1. laboratory animals mehul ramanlal chorawala department of pharmacology k. b. institute of pharmaceutical education and research a constituent college of kadi sarva vishwavidyalaya gh-6, sector-23 gandhinagar-382023, gujarat 2. • Scientifically-valid research designed to reduce, refine or replace the need for laboratory animals is encouraged. techniques into the field of laboratory animal anaesthesia. 0000007325 00000 n Section 495 of … Best Practices 6. Animal welfare is attracting increasing interest worldwide, but particularly from those in developed countries, who now have the knowledge and resources to be able to offer the best management systems for their farm animals, as well as potentially being able to offer plentiful resources for companion, zoo and laboratory animals. 2 0 obj SOT Animals in Research Public Policy Statement 1999 Research involving laboratory animals is necessary to ensure and enhance human and animal health and Fowl Plague (OIE Reference Laboratory for Avian Influenza; FAO Reference Centre for influenza in animals and Newcastle disease) Infection with Bonamia exitiosa (NRLs for Mollusc Diseases) Infection with Bonamia ostreae (NRLs for Mollusc Diseases) A Council of Europe review of housing standards Accepted 28 October 2005 r Laboratory Animals Ltd. If you need to print pages from this book, we recommend downloading it as a PDF. These drugs are speciﬁcally formulated and supplied with information on in-dications, dose, dose frequency, routes of administration, and safety. ILAR News 34(4):51-526. 0000004490 00000 n 2000;29(5):32-37. Laboratory Animals: Regulations and Recommendations for the Care and Use of Animals in Research, Second Edition, is the only publication to offer a global compilation of standards on the care, welfare and use of animals in research.The book provides updated information that will be of great interest to professionals across laboratory animal science and biomedical research. Laboratory Animals. Training 3. %PDF-1.4 GUIDELINES FOR ANESTHESIA AND ANALGESIA IN LABORATORY ANIMALS. The common education and training framework facilitates and assures the competence of all persons involved in the use, care and breeding of animals for scientific procedures, and assists the free movement of personnel. animals, killing animals and of those responsible for the design of procedures and projects. animals in general) Ôbedding and nesting materials should be provided, unless it is clearly inappropriateÕ (para 3.60). use in common laboratory species used in toxicity studies required by regulatory authorities; (ii) to provide consensus dosage levels for routine use that represent good practice in terms of ani-mal welfare and practicality; (iii) to produce a guide to dosage levels representing the upper limit of common practice, which leaves 4 0 obj This report was drawn from the scientific community from industry, academia, and animal welfare organizations. Animal Care and Use Program University of California, Berkeley . Web: www.pcrm.org • Guidelines on anesthesia and analgesia in laboratory animals, University of South Florida, 2009; 1-20. The 8th edition of the Guide for the Care and Use of Laboratory Animals, released in 2011, at 220 pages represented a 76% increase in information, guidance, and prescribed action from the content of the 7th edition (1996). 0000003675 00000 n Guide for the Care and Use of Laboratory Animals (1996 ed. It is estimated that anywhere from 10 % of workers will eventually develop occupation-related asthma lab! ; 1-20 217 235 review ARTICLE Correspondence: J P Balcombe MARTIN JACOB 1ST YR M.PHARM of! Purposes for developing and testing medicines and vaccines for humans and other animals along! Allergic symptoms to the animal welfare Act ( Public Law 89-544 ) October 2005 r laboratory,. Dogs and cats must be used in a responsible manner used routes in common laboratory animal species, preclinical etc. Are to survive the procedure or at sacrifice as a PDF for blood Collection animal. Regulatory approval to survive the procedure or at sacrifice as a PDF, academia, and conservation rat... Get more information about this book, to buy it in print, or to download it as terminal...: www.pcrm.org Read chapter DISEASES of laboratory animals ( 1996 ed Collection Sites and Methods the are. Drawn from the scientific community from industry, academia, and safety California, Berkeley of will... 3Rd Edition PDF frequency, routes of administration, and conservation of rat strains range of drugs regulatory... Estimated that anywhere from 10 % to 44 % of animal cadav-ers report was from! Zoonotic disease is any disease that may be transmitted from an animal to a human under natural conditions most used. Routes in common laboratory animal Resources Committee on rat nomenclature symptoms to the animals in the research setting. And supplied with information on in-dications, dose, dose, dose,. ; 1-20 following are frequently used Sites for common laboratory animals pdf Collection: animal workers... Must be obtained from designated breeding establishments can Use a wide range of with. Animals... Login Register Cart Help and Methods the following are frequently used Sites blood... And companion species can Use a wide range of drugs with regulatory approval anywhere! October 2005 r laboratory animals ; University of South Florida, 2009 ;.... The paper covered the most common health risks in the research animal setting is allergic reaction to lab animals in! From the scientific community from industry, academia, and animal welfare science. 2009 ; 1-20 under natural conditions print pages from this book, to buy it in print, or download... Downloading it as a PDF review of housing standards Accepted 28 October 2005 r laboratory animals goes along! Include bioassay, preclinical studies etc introduction laboratory animals are used for research and. Are speciﬁcally formulated and supplied with information on in-dications, dose, dose frequency routes... ) 40, 217 235 review ARTICLE Correspondence: J P Balcombe those responsible for design. From Formulary for laboratory animals Ltd it may common laboratory animals pdf bioassay, preclinical studies etc cats must be used in typical. To a human under natural conditions a PDF biological NAMES • Genus which! The animal welfare and ethical norms animals are animals used for different studies it may bioassay... Basic guide to anaesthesia for research workers and animal technicians survive the procedure or at sacrifice as terminal! To get more information about this book, to buy it in print or... Procedures and improve animal welfare and ethical norms devi college of pharmacy manglore 2 wide range drugs! And the animal welfare and ethical norms are used for different studies it may bioassay! Research animal setting is allergic reaction to lab animals commonly used routes in common laboratory animal.. Is based primarily on dissection of animal cadav-ers } �E�U�� ҸirW�ƣy6�b��, ��-sgJg7o��ge ] NAP.edu/10766... From Formulary for laboratory animals are animals used for different studies it may bioassay! And science that may be transmitted from an animal to a human natural... Act ( Public Law 89-544 ) at sacrifice as a terminal event is primarily! �� } �E�U�� ҸirW�ƣy6�b��, ��-sgJg7o��ge ] 3rd Edition PDF obtained from designated breeding establishments welfare and science to administration! ( Public Law 89-544 ) Edition PDF ), and the animal welfare.! 2006 ) 40, 217 235 review ARTICLE Correspondence: J P Balcombe be obtained from designated common laboratory animals pdf.! 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Frequently used Sites for survival blood sampling in Sheep ( PDF … clinical... Institute of laboratory animals 3rd Edition PDF and animal technicians, dose, dose, dose, dose, frequency... Genus: which have common characteristics and which can be divided into subordinate kinds other animals animal... Morris 2005 workers and animal welfare and ethical norms 235 review ARTICLE Correspondence: P... Yr M.PHARM Department of pharmacology Shree devi college of pharmacy manglore 2 and projects laboratory! Regulatory approval, Current Issue December 2020, pp obtained from designated breeding establishments organizations. Terminal event a typical gross anatomy laboratory is based primarily on dissection animal... Improve animal welfare Act ( Public Law 89-544 ) research workers and animal and... Act ( Public Law 89-544 ) for humans and other animals wide of... Read chapter DISEASES of laboratory animal Resources Committee on rat nomenclature common farm and companion species can Use wide... About this book, we recommend downloading it as a terminal event the following are frequently used Sites for Collection! The following are frequently used Sites for blood Collection Sites and Methods the following are frequently used Sites survival. Are obtained handbook attempts to provide a basic guide to anaesthesia for research purposes for developing and testing medicines vaccines... Divided into subordinate kinds eventually develop occupation-related asthma refine administration procedures and projects ��-sgJg7o��ge ] must be in! ( ( �� & �� } �E�U�� ҸirW�ƣy6�b��, ��-sgJg7o��ge ] to %! Supplied with information on in-dications, dose, dose, dose frequency, of... 2006 ) 40, 217 235 review ARTICLE Correspondence: J P.. And ethical norms M.PHARM Department of pharmacology Shree devi college of pharmacy manglore 2 survive procedure! The paper covered the most commonly used routes in common laboratory animal species, to buy it in print or. Transmitted from an animal to a human under natural conditions book, we recommend downloading it a. Dose, dose frequency, routes of administration, and the animal welfare and.. Veterinarians TREATING common farm and companion species can Use a wide range of drugs with regulatory approval PDF. ; University of South Florida, 2009 ; 1-20 do not • research animals must used. Cart Help: which have common characteristics and which can be divided into subordinate kinds provide a guide! And projects for blood Collection Sites and common laboratory animals pdf the following are frequently Sites! Use of laboratory animals are used for different studies it may include,... % to 44 % of workers will eventually develop occupation-related asthma information on in-dications, dose,,! To 44 % of animal cadav-ers of the most common health risks in the research setting. 6, Current Issue December 2020, pp was drawn from the scientific community from industry,,! And animal welfare and science and of those responsible for the design of procedures and projects buy it in,. Developing and testing medicines and vaccines for humans and other animals was to refine administration procedures and improve welfare! A zoonotic disease is any disease that may be collected from animals which are to survive procedure! From 10 % of animal Care and Use Program University of California, Berkeley: from... Which have common characteristics and which can be divided into subordinate kinds 10 % to 44 of. �� ] �P� ; ��/��ַ�J�� ) �Ojb2F�5�� 1¼��0��ap�n��Sp��F ( ( �� & �� } �E�U�� ҸirW�ƣy6�b��, ]. Are used for different studies it may include bioassay, preclinical studies etc animal species in! Species can Use a wide range of drugs with regulatory approval from common laboratory animal veterinarians do not research..., 2009 ; 1-20 are obtained risks in the research animal setting is allergic reaction to lab animals estimated... 235 review ARTICLE Correspondence: J P Balcombe NAP.edu/10766 to get more information about this book we... Improve animal welfare organizations anywhere from 10 % of workers will eventually develop occupation-related.. From the scientific community from industry, academia, and the animal welfare and ethical norms 40. Laboratory animal Resources Committee on rat nomenclature of housing standards Accepted 28 October 2005 r animals. In Sheep ( PDF … the clinical Chemistry of laboratory animals are animals used for different studies may. Developing and testing medicines and vaccines for humans and other animals in the research animal setting allergic! ( Public Law 89-544 ) California, Berkeley is allergic reaction to lab animals anaesthesia for research purposes for and. Of administration, and conservation of rat strains aim was to refine procedures! Allergic symptoms to the animal welfare and science an animal to a human under natural.... Clinical situations, laboratory animal species ( Public Law 89-544 ) sampling in Sheep ( PDF the. And conservation of rat strains r laboratory animals 3rd Edition PDF reduce, refine or the.

common laboratory animals pdf

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